Calculated physical and biological results when negatively charged pions are used to irradiate a small and a large ''tumor'' volume in a tissue phantom

Technical Report · Fri Mar 01 04:00:00 EDT 1974

DOI:https://doi.org/10.2172/4310171· OSTI ID:4310171

Santoro, R. T.; Alsmiller, Jr., R. G.

The calculated absorbed dosss, LET spectra, cell-survival probabilities, oxygen enhancement ratios, and relative biological effectiveness are presented and compared for two negatively charged pion beams, each incident on a 30-cm- thick tissue phantom. All of the biological results were obtained using the cellinactivation model of Katz et al and parameters for T-1 human kidney cells. The beam parameters were chosen to produce an approximately uniform absorbed dose in a small (2 cm in depth and 1 cm in radius) and in a large (5 cm in depth and 2.5 cm in radius) cylindrical tissue volume, each centered about a depth of 15 cm in the phantom. (auth)

• Research Organization: Oak Ridge National Lab., Tenn. (USA)
• DOE Contract Number: W-7405-ENG-26
• NSA Number: NSA-29-024482
• OSTI ID: 4310171
• Report Number(s): ORNL-TM--4490
• Country of Publication: United States
• Language: English

Related Subjects

*NEOPLASMS-- RADIATION DOSE DISTRIBUTIONS
*PIONS MINUS-- RBE
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
LET
N48210 --Life Sciences--Radiation Effects on Cells--External Source
N48510* --Life Sciences--Radiation Effects on Animals--Man
OXYGEN ENHANCEMENT RATIO
PATIENTS
PHANTOMS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
SURVIVAL TIME
TISSUE- EQUIVALENT MATERIALS
VOLUME