Biological effects of negative pions

Conference · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4421026

Raju, M R

From thirteenth international congress of radiology; Madrid, Spain (15 Oct 1973). A brief review is presented of studies on biological effects of negative pions. Studies on biological effectiveness at the plateau were conducted using mice with ascites tumors, the RBE relative to /sup 60/Co gamma radiation was nearly 1.0. Studies on biological effectivenes s and oxygen enhancement ratio using root growth of Vicia faba showed that the RBE was 1.31 and the OER was 2.04. RBE and OER were measured in various biologica1 systems and the results at the peak of the depth-dose distribution are tabulated. Results of studies on human kidney- cells, bean roots, and HeLa cells are reviewed with regard to variations in biologica1 effectiveness within the peak regdon. Ce1l survival calculations are reviewed with emphasis on cell survival data at various descrete LET values. A discussion is presented of the biological effects of negative pion beams of interest for therapy-. (HLW-)

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• NSA Number: NSA-29-000632
• OSTI ID: 4421026
• Report Number(s): LA-UR--73-1389; CONF-731012--2
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- SURVIVAL CURVES
*PIONS MINUS-- RBE
*RADIOTHERAPY-- PION BEAMS
ASCITES TUMOR CELLS
BIOLOGICAL EFFECTS
DEPTH DOSE DISTRIBUTIONS
MICE
N48200 --Life Sciences--Radiation Effects on Cells
N48510* --Life Sciences--Radiation Effects on Animals--Man
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