Effects of bone in the use of negatively charged pions in cancer radiotherapy

Technical Report · Fri Feb 01 04:00:00 EDT 1974

DOI:https://doi.org/10.2172/4347239· OSTI ID:4347239

Santoro, R. T.; Alsmiller, Jr., R. G.; Chandler, K. C.

The effects of bone in the use of negatively charged pions in cancer treatment planning have been estimated using Monte Carlo methods. The influence of bone along the pion path and also the influence of a bone-tissue interface parallel to the direction of motion of the pions were considered. Calculated results of absorbed dose, cell-survival probability, oxygen enhancement ratio, and relative biological effectiveness as a function of spatial coordinates in a 30-g-cm/sup -2/-thick tissue phantom with bone both included and excluded are presented. All of the biological data reported here are fur T-1 human kidney cells. The extent to which the effects of bone in the path of the pion beam can be approximated by using results for tissue and measuring depth in the phantom in g cm/sup -2/ is considered and discussed. (auth)

• Research Organization: Oak Ridge National Lab., Tenn. (USA)
• DOE Contract Number: W-7405-ENG-26
• NSA Number: NSA-29-021156
• OSTI ID: 4347239
• Report Number(s): ORNL-TM--4407
• Country of Publication: United States
• Language: English

Related Subjects

*BONE TISSUES-- RADIATION DOSE DISTRIBUTIONS
*PIONS-- RADIATION DOSE DISTRIBUTIONS
*RADIATION DOSE DISTRIBUTIONS-- COMPUTER CALCULATIONS
*RADIOTHERAPY-- RESEARCH PROGRAMS
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
DEPTH DOSE DISTRIBUTIONS
KIDNEYS
MONTE CARLO METHOD
N48510* --Life Sciences--Radiation Effects on Animals--Man
NEOPLASMS
NONUNIFORM IRRADIATION
OXYGEN ENHANCEMENT RATIO
PHANTOMS
PION BEAMS
RADIATION DOSES
RBE
SPATIAL DOSE DISTRIBUTIONS
SURVIVAL TIME
TISSUES