MORPHOLOGICAL CHANGES IN THE BONES OF RATS AFFECTED BY RADIOACTIVE YTTRIUM- 91

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4309782

Litvinov, N N

About 0.6 microcurie per kilogram of body weight was introduced intraperitoneally to 70 white rats. During the first month the process of osteogenesis was depressed, while the process of bone dissolution and development of osteogenic tissue in the periphery of bone structures was enhanced. In the following 2 to 6 months the process of endochondral ossification was retarded. Later it was observed that endochondral ossification stopped prematurely. The most pronounced changes were revealed in metaphyses of long bones during the first 2 to 6 months. They consisted in progressive disturbance of the processes of osteogenesis with formation of immature fibrous structures and development of osteogenic tissue. Later, the changes of osteogenic tissue brought about the development of malignant growth. Bone tumors appeared in metaphyses of long bones and in the majority of cases were of osteoplastic character. Osteogenic sarcomas developed in 17 rats out of 25 which were sacrificed in 165 days or later after the introduction of the radioactive substance. (tr-auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-12-009596
• OSTI ID: 4309782
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 3, No. 1; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
BONES
CARCINOGENESIS
CYTOLOGY
METABOLISM
RADIATION EFFECTS
RATS
SARCOMAS
TUMORS
YTTRIUM 91