MORPHOLOGICAL CHANGES OF BONE TISSUE IN ACUTE AND SUBACUTE PLUTONIUM POISONING (in Russian)
Journal Article
·
· Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
OSTI ID:4236990
Experiments were conducted on 70 white rats who received intraperitoneally plutonium-239. Considerable changes were seen in the bone tissue upon administration of 0.15, 0.08, 0.04, and 0.02 mu c/gm body weight. The changes were most pronounced in the long bones and had a definite sequence of development. In the first days following the administration of plutonium there was an increase of bone resolution with development or cellular-fibrous tissue containing a large quantity of osteoblasts. After the second week a gradual inhibition of the processes of enchondral ossification ensued, with reconstruction of the bone and a drop of the amount of osteoblasts. At the height of affection (3 to 5 weeks) total inhibition of the processes of osteogenesis with death of osteogenic tissue was observed. In animals receiving plutonium with specific activity of 0.04 and 0.02 mu c/mg body weight, the disturbance of osteogenesis was marked to a lesser degree than in introduction of 0.15 and 0.08 mu c/gm; in the second month the growth of bones was restored to a certain extent. The formation of a large quantity of immature bone tissue was seen in the metaphyses and diaphyses. At the end of the third month premature cessation of the bone growth took place. The amount of immature bone in various portions of the skeleton increased. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-13-015890
- OSTI ID:
- 4236990
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 5; ISSN MERAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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