Histological Response of the Duodenum to X-Irradiation in Hypophysectomized Rats

Journal Article · Tue Jul 01 04:00:00 EDT 1958 · Radiation Research

DOI:https://doi.org/10.2307/3570780· OSTI ID:4301602

Baker, Burton L.; Kent, John F.; Pliske, Edward C.

Thirty to 81 days after hypophysectomy of the rat there was a reduction in thickness of the duodenal mucosa accompanied by reduction in size of villi and crypts of Lieberkuhn. The epithelial cells associated with these structures were somewhat smaller and in the crypts exhibited a moderate reduction in intensity of cytoplasmic basophilia. Paneth cells were smaller and contained fewer serious granules and less cytoplasmic ribonucleic acid. Total-body x-radiation was administered to hypophysectomized rats 20 to 43 days after the operation at doses of 500 r, 600 r, 775 r, and 1200 r. Nonhypophysectomized controls were treated similarly. After allowance was made for the histo logical alterations induced by hypophyssotomy alone, the histological changes elicited by x-radiation, or the rate of recovery from them, were not significantly different in hypophyseotomized as compared with nonhypophysectomized rats.

• Research Organization: Univ. of Michigan, Ann Arbor
• Sponsoring Organization: USDOE
• NSA Number: NSA-12-012133
• OSTI ID: 4301602
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 9; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
CYTOLOGY
DUODENUM
GLANDS
HYPOPHYSIS
INTESTINE
RADIATION DOSES
RADIATION INJURIES
RATS
RECOVERY
RIBONUCLEIC ACID
SURGERY
X RADIATION