Effect of antisecretory agents and vagotomy on healing of chronic cysteamine-induced duodenal ulcers in rats

Journal Article · Tue Jul 01 04:00:00 EDT 1986 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01296454· OSTI ID:5143793

Poulsen, S S; Raaberg, L; Therkelsen, K; Skov Olsen, P; Kirkegaard, P

Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.

• OSTI ID: 5143793
• Journal Information: Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 7; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AZOLES
BENZIMIDAZOLES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
DRUGS
GASTRIC ACID
GASTROINTESTINAL TRACT
HEALING
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INTESTINES
MAMMALS
MATERIALS
MEA
MEDICINE
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOPROTECTIVE SUBSTANCES
RATS
RECOVERY
RODENTS
SMALL INTESTINE
SURGERY
THERAPY
THIOLS
TOXICITY
ULCERS
VAGUS
VERTEBRATES