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Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing

Journal Article · · Dig. Dis. Sci.; (United States)
DOI:https://doi.org/10.1007/BF01535782· OSTI ID:7092865
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The healing process of cysteamine-induced duodenal ulcer was studied by (/sup 3/H)thymidine autoradiography. After the development of ulcer in the duodenum, cell proliferation was markedly activated not only in the crypts but also in the Brunner's glands near the ulcer. In the initial stages of ulcer healing, they both contributed to form the surface covering regenerating epithelium. Granulation tissue also proliferated at the base of the ulcer. In later stages of ulcer healing, new crypts were formed in the floor of the ulcer. New villi regenerated from these crypts and Brunner's glands regenerated by proliferation in situ. The ulcer base then was completely covered with new villi and granulation tissue was replaced by dense fibrous connective tissue. The present study suggested that the Brunner's glands, together with the crypts of Lieberkuehn, play an important role in the healing process of cysteamine-induced duodenal ulcer.
Research Organization:
Kyoto Prefectural Univ. of Medicine (Japan)
OSTI ID:
7092865
Journal Information:
Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 33:9; ISSN DDSCD
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL RECOVERY
BODY
CELL PROLIFERATION
DIGESTIVE SYSTEM
EPITHELIUM
GASTROINTESTINAL TRACT
HEALING
HETEROCYCLIC COMPOUNDS
INTESTINES
LABELLED COMPOUNDS
MAMMALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PYRIMIDINES
RATS
RECOVERY
RIBOSIDES
RODENTS
SMALL INTESTINE
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
ULCERS
VERTEBRATES