RESTORATION PROCESSES IN THE MUCOUS MEMBRANE OF THE DUODENUM AFTER INJURY BY RADIATION

Journal Article · Wed Aug 21 04:00:00 EDT 1963 · Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals

OSTI ID:4635137

Chalisov, I A; Berlin, L B

Changes in the mucous membrane of the duodenum were followed in 111 rats from 0 hours to 15 days after administering a single, Co/sup 60/ dose of 900 r. The survival of the rats was 50% after 11 to 14 days. Parts of the duodenum were fixed in formaldehyde and wax, and paraffin sections 5 to 7 mu were stained with iron hemitoxylin, eosin, red aniline dye, methyl green, and other reagents for the hematological studies. The mitotic coefficient dropped from a normal value of 5.4% to a low value of 0.05% a few hours after the irradiation in the epithelial cells of the mucous membrane. The mitotic coefficient increased to 1% after a few days. On the second day, destructive processes were noted which resulted in the loss of the entire epithelial covering of the duodenum and inflammation in the mucous membrane with a temporary disappearance of the villi. Restoration processes in the epithelium began on the third day with an increase in activity of the crypt cells from 2% to a final 5.7%. The epithelium began to differentiate and reform. The surface of the duodenum became almost smooth. New villi appeared in places. This period of intensive restorative changes in the duodenum coincides with the beginning of severe radiation sickness with bleeding in the animal. On the 10th day, the crypts and villi were normal in appearance and structure, even though 50% of the animals died from the severe radiation sickness on the 11th to 14th day. (TTT)

• Research Organization: Kirov Military Academy of Medicine, USSR
• NSA Number: NSA-17-040669
• OSTI ID: 4635137
• Journal Information: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 151; ISSN DANKA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
BLOOD CELLS
COBALT 60
CYTOLOGY
DUODENUM
DYES
HEMORRHAGE
INTESTINE
IRRADIATION
LETHAL DOSE
MICROSCOPY
MITOSIS
PERFORMANCE
RADIATION DOSES
RADIATION INJURIES
RADIATION SICKNESS
RECOVERY
REGENERATION
STANDARDS
SURVIVAL TIME
TISSUES
VARIATIONS