LIMITATION OF RADIOIODINE AS A LABEL FOR FAT
Journal Article
·
· Journal of Laboratory and Clinical Medicine (U.S.)
OSTI ID:4297001
Chemical procedures for the determination of I/sup 131/ lipid fractions in whole blood, plasma, and tissues are discussed. I/sup 131/-labeled triolein, administered intravenously as an emulsion, disappcars at the same rate as natural fats. Afier oral administration of I/sup131/ triolein the concentration of I/sup 131/ triglyccride in dog plasma during the period of alimentary lipemia is lower than that of the chemically determined fat. This difference between the specific activity of fed fat and plasma fat already exists in lymph, as shown by the low specific activity of dog and rat lymph compared to that of the administered fnt. Comparison of I/sup 131/ and C/sup 14/ triolein showed that dilution by an endogenous triglyceridc pool cannot account for the observed decrease in specific activity. The distribution of orally administered C/sup 14/ oleic acid and C/sup 14/ stearic acid in the neutral fat fraction of carcass is faily similar to that of I/sup 131/ oleic acid. However, in liver, where rapid incorporation of C/sup 14/labeled fatty acids into phospholipid fractions occurs, I/sup 131/ oleic acid was found to be absent and thus gives ana erroneous picture of the distribution of dietary fatty acids. (auth)
- Research Organization:
- Univ. of Tennessee, Memphis
- NSA Number:
- NSA-13-001919
- OSTI ID:
- 4297001
- Journal Information:
- Journal of Laboratory and Clinical Medicine (U.S.), Journal Name: Journal of Laboratory and Clinical Medicine (U.S.) Vol. Vol: 52; ISSN JLCMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BIOLOGY AND MEDICINE
BLOOD
BLOOD PLASMA
BLOOD VESSELS
BONES
CARBON 14
DIET
DISTRIBUTION
DOGS
EMULSIONS
IODINE 131
LABELLED COMPOUNDS
LIPIDS
LIVER
LYMPH SYSTEM
MEASURED VALUES
METABOLISM
OLEIC ACID
ORGANIC ACIDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
RATS
STEARIC ACID
TISSUES
TRACER TECHNIQUES
TRIGLYCERIDES
TRIOLEIN
BLOOD
BLOOD PLASMA
BLOOD VESSELS
BONES
CARBON 14
DIET
DISTRIBUTION
DOGS
EMULSIONS
IODINE 131
LABELLED COMPOUNDS
LIPIDS
LIVER
LYMPH SYSTEM
MEASURED VALUES
METABOLISM
OLEIC ACID
ORGANIC ACIDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
RATS
STEARIC ACID
TISSUES
TRACER TECHNIQUES
TRIGLYCERIDES
TRIOLEIN