Myocardial uptake of labeled oleic and linoleic acids

Journal Article · Mon Sep 01 04:00:00 EDT 1975 · J. Nucl. Med., v. 16, no. 9, pp. 842-845

OSTI ID:4162114

Beierwaltes, W H; Ice, R D; Shaw, M J; Ryo, U Y

Oleic acid labeled with $sup 14$Ca, ($sup 14$C-OA) or $sup 131$I ($sup 131$I-OA) and $sup 131$I- labeled linoleic acid ($sup 131$I-LOA) were administered intravenously to rats and tissue distribution studies completed at various time intervals from 5 to 60 min. Tissue distribution of $sup 131$I- labeled oleic acid or linoleic acid was also studied in dogs at 5- and 30-min time intervals after intravenous administration of the tracer dose. There were distinct differences in the patterns of tissue distribution between $sup 14$C-OA: $sup 131$I-OA, and $sup 131$I-LOA. Radioactivity concentration in the myocardium was the highest at all time intervals in the rats given $sup 131$I-OA only. In dogs, the myocardial uptake of $sup 131$I-OA was significantly higher than the radioactivity in the blood or other tissues at 30 min after injection. The disappearance rates of $sup 131$I-OA and $sup 131$I-LOA were almost identical but myocardial concentration of $sup 131$I-LOA at 30 min after the dose in the dog was half that of $sup 131$I-OA whereas $sup 131$I-LOA liver concentration was higher than that of $sup 131$-OA. Since the concentrations of the formulated $sup 131$I-OA in the blood and in the myocardium are both highest at the earlier intervals, it should be difficult to detect myocardial ischemia or infarction with $sup 131$I-OA scanning. (auth)

• Research Organization: Univ. of Michigan, Ann Arbor
• NSA Number: NSA-33-001065
• OSTI ID: 4162114
• Journal Information: J. Nucl. Med., v. 16, no. 9, pp. 842-845, Journal Name: J. Nucl. Med., v. 16, no. 9, pp. 842-845; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*CARBON 14-- TISSUE DISTRIBUTION
*IODINE 131-- TISSUE DISTRIBUTION
*LINOLEIC ACID-- TISSUE DISTRIBUTION
*MYOCARDIUM-- SCINTISCANNING
*OLEIC ACID-- TISSUE DISTRIBUTION
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
DIAGNOSTIC TECHNIQUES
DOGS
HEART
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
RATS
TESTING
UPTAKE