Myocardial uptake of radioiodine-labeled 15-(4-iodophenyl)-9-methylpentadecanoic acid in laboratory animals
A series of experimental iodophenyl fatty acid analogs was synthesized as potential myocardial imaging agents. The biodistribution of radioiodine exchange-labeled fatty acid analogs was determined in female rats. 15-(4-iodophenyl)-9-methylpentadecanoic acid (9-MPDA) exhibited the greatest myocardial uptake specificity in female rats with 5 min heart/blood, heart/liver and heart/lung ratios of approximately 4.3, 1.5 and 3.3, respectively. Monophasic elimination half-lives for radioactivity in the heart and lung were approximately 2 and 12 hr. Elimination of radioactivity from the liver was biphasic with half-lives of 0.1 and 3.0 hr. Following intravenous administration in rabbits, 9-MPDA exhibited highest initial tissue concentrations in the heart and liver, the two organs which most readily metabolize free fatty acids. Gamma camera imaging in dogs following intravenous injection of I-123 9MPDA resulted in good visualization of the myocardium. Maximal heart/liver and heart/background ratios were observed at 30 min after dosing. Radioactivity in myocardial regions of interest fell by half in a period of approximately 70 min corresponding with the time of initial image deterioration. The myocardial uptake specificity of 9MPDA in laboratory animals support clinical evaluation as a diagnostic myocardial imaging agent.
- Research Organization:
- Mallinckrodt, Inc., St. Louis, MO
- OSTI ID:
- 6759262
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CAMERAS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DECANOIC ACID
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
GLANDS
HALF-LIFE
HEART
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RABBITS
RADIOACTIVITY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RESPIRATORY SYSTEM
RODENTS
SYNTHESIS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
USES
VERTEBRATES