LATE EFFECTS OF FAST NEUTRONS VERSUS X-RAYS IN MICE: NEPHROSCLEROSIS, TUMORS, LONGEVITY
Groups of mice exposed to sublethal doses of fast neutrons or to lethal doses of x-rays were followed until natural death in order to study long-term irradiation effects. The x-irradiated mice were protected against acute death by injection of hematopoietic cells or limb shielding. Gastrointestinal carcinomas were much more common in the neutron-irradiated than in the x-irradiated mice. However, in the small group of mice surviving superalethal doses of x rays of 1000 to 1100 r following thigh shielding during exposure, 21% exhibited intestinal carcinomas. A neutron RBE value of 2 to 3 is therefore indicated for these tumors, as late effects. Nephrosclerosis, on the other hand, was more common in the x-irradiated mice, with an apparent neutron RBE value close to unity for this late lesion. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-13-008544
- OSTI ID:
- 4294727
- Report Number(s):
- USNRDL-TR-290
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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