Late effects of total-body roentgen irradiation. Longevity and incidence of nephrosclerosis as influenced by partial body shielding

Technical Report · Fri May 01 00:00:00 EDT 1959

OSTI ID:7214390

Lamson, B G; Billings, M S; Bennett, L R

Two hundred forty-two female Wistar rats were observed throughout their life span following 1,000 R hypoxic total-body or partial-body irradiation. Hypoxic radiation superimposed anesthesia resulted in 67 percent 30 day mortality, compared to 9 percent mortality without anesthesia. Selection of the colony by acute postirradiation deaths did not influence the magnitude of late radiation sequelae as measured by life shortening. Growth retardation during the second postirradiation year was well correlated with life-shortening. Life-shortening was observed after partial-body irradiation to an extent approximately proportional to the weight of radiated tissue. Nephrosclerosis was not observed unless the upper abdomen was included within the radiation field. Other than nephrosclerosis, a similar incidence of disease was observed at death in control and irradiated rats whether partial-body or total-body irradiated.

• Research Organization: School of Aviation Medicine, Randolph AFB, TX (USA)
• OSTI ID: 7214390
• Report Number(s): AD-A-036099; SAM-59-33
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RATS
DELAYED RADIATION EFFECTS
ANIMAL GROWTH
COMPARATIVE EVALUATIONS
LIFE SPAN
NEPHROSCLEROSIS
PARTIAL BODY IRRADIATION
WHOLE-BODY IRRADIATION
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARDIOVASCULAR DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GROWTH
IONIZING RADIATIONS
IRRADIATION
MAMMALS
RADIATION EFFECTS
RADIATIONS
RODENTS
UROGENITAL SYSTEM DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals