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Late effects of total-body roentgen irradiation. Longevity and incidence of nephrosclerosis as influenced by partial body shielding

Technical Report ·
OSTI ID:7214390
; ;
Two hundred forty-two female Wistar rats were observed throughout their life span following 1,000 R hypoxic total-body or partial-body irradiation. Hypoxic radiation superimposed anesthesia resulted in 67 percent 30 day mortality, compared to 9 percent mortality without anesthesia. Selection of the colony by acute postirradiation deaths did not influence the magnitude of late radiation sequelae as measured by life shortening. Growth retardation during the second postirradiation year was well correlated with life-shortening. Life-shortening was observed after partial-body irradiation to an extent approximately proportional to the weight of radiated tissue. Nephrosclerosis was not observed unless the upper abdomen was included within the radiation field. Other than nephrosclerosis, a similar incidence of disease was observed at death in control and irradiated rats whether partial-body or total-body irradiated.
Research Organization:
School of Aviation Medicine, Randolph AFB, TX (USA)
OSTI ID:
7214390
Report Number(s):
AD-A-036099; SAM-59-33
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARDIOVASCULAR DISEASES
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GROWTH
IONIZING RADIATIONS
IRRADIATION
LIFE SPAN
MAMMALS
NEPHROSCLEROSIS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION