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LATE EFFECTS OF TOTAL-BODY ROENTGEN IRRADIATION. IV. HYPERTENSION AND NEPHROSCLEROSIS IN FEMALE WISTAR RATS SURVIVING 1000 r HYPOXIC TOTAL-BODY IRRADIATION

Journal Article · · A.M.A. Arch. Pathol.
OSTI ID:4290319
; ; ;
Systolic blood pressure levels were studied in 59 female Wistar rats surviving 1000 r hypoxic total-body irradiation and in 63 controls of the same age. Mean blood pressure of the irradiated rats at monthly intervals from 13 to 23 months post irradiation averaged 39 mm Hg greater than the controls of the same age. Fonty-six per cent of the irradiated rats also developed bilateral nephrosclerosis. The mean value of maximal blood pressure determinations from individual rats was 193 mm Hg in the irradiated group, compared to 139 mm Hg in the controls. Mean blood pressure maxima in the irradiated rats without severe renal disease was almost as high as in those with nephrosclerosis. No correlation between duration of hypertension and eventual development of nephrosclerosis could be made, but rats with nephroselerosis in no ease had normotensive histories. (auth)
Research Organization:
Univ. of California, Los Angeles
NSA Number:
NSA-13-009571
OSTI ID:
4290319
Journal Information:
A.M.A. Arch. Pathol., Journal Name: A.M.A. Arch. Pathol. Vol. Vol: 66
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
BODY
CONTROL
HYPERTENSION
KIDNEYS
NEPHROSCLEROSIS
OXYGEN
RADIATION EFFECTS
RADIATION INJURIES
RATS
SEX
X RADIATION