LATE SOMATIC EFFECTS OF X-RADIATION IN MICE TREATED WITH AET AND ISOLOGOUS BONE MARROW

Journal Article · Wed Apr 01 04:00:00 EST 1964 · Radiation Res.

DOI:https://doi.org/10.2307/3571651· OSTI ID:4016311

Cosgrove, G E; Upton, A C; Congdon, C C; Doherty, D G; Christenberry, K W; Gosslee, D G

Young adult female (101 x C3H)F/sub 1/ mice were exposed to a sublethal or lethal x-ray dose (350 to 1800 r), with or without treatment by the radioprotective chemical S 2aminoethylisothiuronium. Br. HBr (AET) before irradiation or isologous bone marrow (IBM) after irradiation. Sixty-day survivors were observed until death, necropsied, and examined pathologically. Irradiation shortened the life span to an extent that varied with the dose, but the degree of life shortening per roentgen decreased with increasing dose. Although AET and IBM had markedly protective effects against early lethality, their effectiveness in protecting against reduction of longevity in long-term survivors was equivocal. Sixty-six per cent of controls died with neoplasms, the most common of which arose in the ovary, lung, uterus, and breast. Ovarian and mammary tumors were more numerous in the irradiated groups, whereas pulmonary and uterine tumors were more numerous in unirradiated controls. AET and IBM were without effect on the incidence of these growths. Thymic lymphoma was increased in frequency by irradiation, as was myeloid leukemia. The incidence of other neoplasms of blood-forming elemnents was reduced in irradiated animnals. AET and IBM inhibited the induction of thymnic lymphomas. Nephrosclerosis occurred in a high percentage of heavily irradiated (>750 r) long-term survivors. The incidence was not affected by AET or IBM. Graying of the fur was noted at all radiation levels. Its severity varied with the dose and was reduced by AET. Lens opacities developed in all aging mice, including the controls. The rapidity of onset, rate of progression, and final severity of opacification increased with increasing dose of x rays. The developmnent of opacities was not detectably affected by AET or IBM. From the results of this study, it is evident that AET and IBM protected against some but not all delayed somatic effects of whole-body x irradiation, although in no case did the protection appear to afford a factor of dose reduction approximating that obtained against the acutely lethal effects of the radiation (i.e., 40 to 50%). Further knowledge of the relation between the radiation dose and the late effects in question will be necessary before the kinds and degrees of protection afforded by AET and IBM can be defined precisely. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019796
• OSTI ID: 4016311
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 21
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
BIOLOGY AND MEDICINE
BONE MARROW
CARCINOGENESIS
CATARACTS
DISEASES
DRUGS
EFFICIENCY
EYES
GLANDS
GONADS
HAIR
IRRADIATION
KIDNEYS
LENSES
LETHAL DOSE
LEUKEMIA
LUNGS
LYMPH SYSTEM
LYMPHOMAS
MAMMARY GLANDS
MICE
NUMERICALS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OVARIES
PIGMENTS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
SEX
SKIN
STANDARDS
STATISTICS
SURVIVAL TIME
THYMUS
TISSUES
TRANSPLANTS
TUMORS
UTERUS
VARIATIONS
X RADIATION