Late somatic effects in mice after total lymphoid irradiation

Journal Article · Thu Dec 01 04:00:00 EST 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577392· OSTI ID:6536980

Covelli, V; Di Majo, V; Coppola, M; Rebessi, S; Bangrazi, C; Doria, G

Late somatic effects of total lymphoid irradiation have been investigated in BC3F1 mice. A total X-ray dose of 34 Gy was distributed in 17 daily fractions. The cumulative mortality curve is shifted in time because all the irradiated mice died earlier than the unirradiated controls. There was a 24% shortening of life span. A marked increase of solid tumor incidence, mostly due to skin cancers, was observed (66% vs 30%). In contrast, the incidence of malignant lymphomas was greatly reduced in irradiated mice (6% vs 49%). Furthermore, nephrosclerosis was a common finding in the irradiated group (38% vs 8%). Death-rate analysis revealed an association between life shortening and the presence of solid tumors and nephrosclerosis at death.

• Research Organization: ENEA CRE Casaccia, Rome (Italy)
• OSTI ID: 6536980
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 116:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
IRRADIATION
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
NEOPLASMS
NEPHROSCLEROSIS
RADIATIONS
RADIOINDUCTION
RODENTS
SURVIVAL CURVES
UROGENITAL SYSTEM DISEASES
VASCULAR DISEASES
VERTEBRATES
X RADIATION