THE EFFECT OF SUBCUTANEOUSLY INJECTED COBALT ON THE ERYTHROPOIETIC ACTIVITY AND RADIOSENSITIVITY OF X-IRRADIATED MICE
Technical Report
·
OSTI ID:4294616
A single subcutaneous dose of 1.0 mg cobaltous chloride per 10 g body weight stimulated the erythropoietic activity of mice surviving the toxic effects. Single doses below this level gave little indication of increasing the red blood cell count while doses beyond this level were lethal to all mice. Daily subcutaneous injections of 0.8 mg cobaltous chloride per 10 g body weight increased red blood cell formation in mice that survived the tioxic effects. With daily subcutaneous injections given in combination with a single lethal dose of x rays, cobalt's erythropoietic stimulating property was less obvious, but an increase in radiosensitivity was observed. Daily doses of less than 0.6 mg cobaltous chloride per 10 g body weight had little effect on the red cell count or on the radiosensitivity. (auth)
- Research Organization:
- Army Medical Research Lab., Fort Knox, Ky.
- NSA Number:
- NSA-12-010320
- OSTI ID:
- 4294616
- Report Number(s):
- AMRL-332
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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