AN IMMUNOGENETIC STUDY OF THE MECHANISMS OF PROTECTION AGAINST RADIATION DEATH BY TREATMENT WITH HAEMOPOIETIC TISSUES. Research Report, December 1, 1962 to July 31, 1963

Technical Report · Thu Oct 31 04:00:00 EST 1963

OSTI ID:4668067

Hoecker, G

A method of in vivo culture without transplantation for the study of radiosensitivity of erythropoietically competent stem cells was developed. The results showed that the relation of red blood cell Fe/sup 59/ to irradiation is exponential with a D/sub 37/ of 81 r. The technique was used to study the effects of dose fractionation on recovery of erythropoiesis after irradiation. The results show that when the interval between the two doses is 5 hr, r.b.c. Fe/sup 59/ is about 3 times that of mice receiving the same total dose in one exposure. Analysis of the survival of lethally irradiated coisogenic hosts protected with isogenic and allogenic B.M. infusions differing at H-2 showed a significant difference in mortality during the first two weeks. Cortisone was found to have a detrimental effect on the mice. (P.C.H.)

• Research Organization: Chile. Universidad, Santiago
• NSA Number: NSA-17-035600
• OSTI ID: 4668067
• Report Number(s): TID-19293
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD FORMATION
CORTISONE
DOSE FRACTIONATION
DRUGS
ERYTHROCYTES
IMMUNITY
IRON 59
MICE
RADIATION DOSES
RADIATION PROTECTION
RADIOSENSITIVITY
STEROIDS
SURVIVAL TIME
TRANSPLANTS