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AN IMMUNOGENETIC STUDY OF THE MECHANISMS OF PROTECTION AGAINST RADIATION DEATH BY TREATMENT WITH HAEMOPOIETIC TISSUES. Research Report, December 1, 1959 to October 31, 1962

Technical Report ·
OSTI ID:4840063
The relative importance of specific histocompatible loci in the protection afforded by homologous bone marrow to lethally irradiated mice was studied. The complex antigenic differences existing when combinations of B.M. donors and irradiated hosts differ in an unknown number of H-genes into its main components were resolved. Data are given on the contributions to B.M. protection of loci H-1, H-2, and H-3 in different combinations of irradiated hosts and B.M. donors, on the combined effects of H-1 plus H-2, H-2 plus H-3, and H-1 plus H-3, and on the effects of immunizing either B.M. donors or hosts against the well defined H-gene differences. An unexpected finding was that some coisogenic F/sub 1/ hybrid donors do not give good protection against hosts. (P.C.H.)
Research Organization:
Chile. Universidad, Santiago
NSA Number:
NSA-17-035454
OSTI ID:
4840063
Report Number(s):
TID-19291
Country of Publication:
United States
Language:
English