THE INFLUENCE OF IONIZING RADIATIONS ON THE PENETRATION OF SODIUM INTO THE CENTRAL NERVOUS SYSTEM

Journal Article · Mon Dec 01 04:00:00 EST 1958 · Intern. J. Appl. Radiation and Isotopes

DOI:https://doi.org/10.1016/0020-708X(58)90026-7· OSTI ID:4283906

Rose, R G

High doses of irradiation are required to prcduce definite morphological changes in the central nervous system. The present experiment was conducted to see if functional derangements occur after comparatively small amounts of ionizing radiations. Tracer studies with intravenously injectcd radioactive sodium were performed on rabbits to determine the rate and degree of sodium penetration into the cerebro-spinal fluid and brain. Other groups of rabbits were given large doses of Na/sup 24/ or 100 to 1500 r of total-bcdy x irradiation, followed by tracer doses of Na/sup 24/ at varying intervals, to study the possible effects of such irradiation. The data obtained showed an accelerated penetration of sodium into the CNS under these condations, as well as an apparent increase in radioscdium content in the CNS when compared with the control group. Histological changes were minimal at the highest dosage levels employed. The significance and possible applications of these findings are discussed. (anth)

• Research Organization: Univ. of Texas, Houston
• NSA Number: NSA-13-004413
• OSTI ID: 4283906
• Journal Information: Intern. J. Appl. Radiation and Isotopes, Journal Name: Intern. J. Appl. Radiation and Isotopes Vol. Vol: 4
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
BRAIN
DIFFUSION
DISTRIBUTION
NERVOUS SYSTEM
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
SODIUM
SODIUM 24
TRACER TECHNIQUES
X RADIATION