Central nervous system complications of non-Hodgkin's lymphoma. The potential role for prophylactic therapy

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Am. J. Med.; (United States)

OSTI ID:6700806

Young, R C; Howser, D M; Anderson, T; Fisher, R I; Jaffe, E; DeVita, Jr, V T

In 38 patients with non-Hodgkin's lymphoma, involvement of the central nervous system (CNS) by malignant lymphoma developed during an eight year period. All patients had lymphomatous meningitis; clinical involvement of the spinal nerves or cranial nerves suggested the diagnosis. Spinal fluid was abnormal in 97% of the patients although a positive cytology could be documented in only 67% by lumbar puncture. The histology in 82% of the patients was diffuse. Involvement of the CNS in nodular lymphoma was uncommon (3%), and the histology in virtually all of these patients had converted to diffuse. At the time of diagnosis of CNS disease, 95% of the patients had other evidence of advanced disease; 66% had bone marrow involvement. In only 18% of the patients did CNS disease develop while they werin clinical remission. Eighty-five percent of the patients treated with whole brain irradiation and intrathecal chemotherapy had a good clinical response. Knowledge of these risk factors permits definition of a group of patients who may benefit from CNS prophylaxis.

• Research Organization: National Cancer Inst., Bethesda, MD
• OSTI ID: 6700806
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 66:3; ISSN AJMEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BONE MARROW
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
DISEASES
HEMATOPOIETIC SYSTEM
HISTOLOGY
IRRADIATION
LYMPHOMAS
MATERIALS
MEDICINE
MEMBRANES
MENINGES
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
SPINAL CORD
THERAPY
TISSUES