Low-Dose Involved-Field Radiotherapy as Alternative Treatment of Nodular Lymphocyte Predominance Hodgkin's Lymphoma
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
- Department of Radiotherapy, Institut Gustave Roussy, Paris (France)
- Department of Radiotherapy, Netherlands Cancer Institute Amsterdam, Amsterdam (Netherlands)
- Clinical Research Unit, Centre Francois Baclesse, Caen (France)
- Department of Medical Oncology, Netherlands Cancer Institute Amsterdam, Amsterdam (Netherlands)
- Department of Pathology, Netherlands Cancer Institute Amsterdam, Amsterdam (Netherlands)
Purpose: Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease. Patients and Methods: A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only. Results: After a median follow-up of 37 months (range, 6-66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9-57 months after radiotherapy. No toxicity was noted. Conclusion: In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity.
- OSTI ID:
- 21276916
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 74; ISSN IOBPD3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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