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THE EFFECT OF PITRESSIN ON POSTIRRADIATION POLYDIPSIA AND POLYURIA IN THE RAT

Journal Article · · Radiation Research
DOI:https://doi.org/10.2307/3570833· OSTI ID:4281747
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The intramuscular injection of 500 mU of Pitressin tannate in peanut oil, either immediately before or immediately after whole-body irradiation by 1500 r of Co/sup 60/ gamma rays, was found to inhibit polydipsia and polyuria in the adult rat. Aqueous solutions of Pitressin. when injected intramuscularly either before or after irradiation, did not inhibit the postirradiation polydipsia and polyuria evoked by 1500 r of whole-body irradiation. Rats deprived of water for the first 24 hours after 500 r of whole-body irradiation did not excrete urine in amounts significantly greater than were excreted by nonirradiated controls. Water intakes and urine outpats during the first 24 hours after 1500 r of whole-body irradiarion decreased linearly with increasing dose of injected Pitressin tannate in peanut oil: 150 mU was found to be the minimum dose of Pitressin which produced a water intake and urine output not significantly different from those of the nonirradiated controls during the first 24 hours postirradiation. The irradiation of Pitressin tannate in peanut oil (in a concentration of 1500 mU/ml) by doses up to 20,000 r did not alter the ability of Pitressin to inhibit the polydipsia and polyuria evoked by 1500 r of whole- body irradiation. (auth)
Research Organization:
Univ. of Texas; U.S. Air Force, Balcones Research Center, Austin, Texas
Sponsoring Organization:
USDOE
NSA Number:
NSA-13-010813
OSTI ID:
4281747
Journal Information:
Radiation Research, Journal Name: Radiation Research Vol. Vol: 10
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
COBALT 60
DIET
GAMMA RADIATION
HORMONES
MEDICINE
POLYDIPSIA
POLYURIA
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RATS
URINE
VARIATIONS
VASOPRESSIN
WATER