POLYDIPSIA AND POLYURIA BY THE X-IRRADIATED RAT

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · American Journal of Physiology (U.S.)

OSTI ID:4242375

Kay, R E; Entenman, C

The results of partial-body x irradiation experiments established the abdomen as the radiosensitive area involved in post-irradiation polydipsia and polyuria. However, the responses do not appear to be due to the action of x rays on any one organ in this region, since x irradiation of individual exteriorized organs was only partially effective. On the other hand, shielding of the exteriorized kidneys or liver was effective in the prevention of postirradiation polyuria and polydipsia. Removal of the adrenal glands or spleen prior to x irradiation did not prevent polydipsia or polyuria, whereas removal of the pancreas greatly diminished the extent of the polydipsia and polyuria and removal of the pituitary gland eliminated the responses. Anoxic anoxia during the time of x irradiation did not prevent polyuria or polydipsia, but when isotonic sugar solutions were given as the drinking fluid polyuria and polydipsia did not occur. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-13-015857
• OSTI ID: 4242375
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 197; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABDOMEN
ADRENAL GLANDS
BIOLOGY AND MEDICINE
BODY
DISTRIBUTION
GLANDS
KIDNEYS
LIVER
MEDICINE
METABOLISM
OXYGEN
PANCREAS
PITUITARY GLAND
POLYDIPSIA
POLYURIA
QUANTITY RATIO
RADIATION EFFECTS
RADIOSENSITIVITY
RATS
SHIELDING
SOLUTIONS
SPLEEN
SUGARS
SURGERY
URINE
VARIATIONS
WATER
X RADIATION