HORMONAL FACTORS INFLUENCING POSTIRRADIATION CREATINURIA AND POLYURIA IN THE RAT

Journal Article · Mon Jun 01 04:00:00 EDT 1959 · American Journal of Physiology (U.S.)

OSTI ID:4249155

Drise, G M; Williams, C M

Normal albino rats exposed to 1500 r of whole-body Co/sup 60/ gamma radiation were found to have a significant increase in urinary creatine excretion for the first 3 postirradiation days. Adrenalectomized rats, irradiated at 8 days postoperatively, did not show a creatinuria significantly greater than nonirradiated controls. Thyroparathyroidectomized rats, irradiated at 8 days postoperatively, did not have a significant increase in urinary creatine excretion over that of nonirradiated fasted uria or polydipsia on the 1st postirradiation day in either the adrenalectomized or thyroparathyroidectomized rats. The intramuscular injection of 500 ic of the antidiuretic hormone vasopressin (Pitressin tannate) in oil inhibited postirradiation polydipsia and polyuria in normal rats but significantly increased the urinary excretion of creatine over that of irradiated noninjected controls. (auth)

• Research Organization: Univ. of Texas, Austin; U.S. Air Force, Balcones Research Center, Austin, Tex.
• NSA Number: NSA-13-014155
• OSTI ID: 4249155
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 196; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
BODY
COBALT 60
CREATINE
GAMMA RADIATION
GLANDS
HORMONES
METABOLISM
MUSCLES
ORGANIC NITROGEN COMPOUNDS
PARATHYROIDS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SURGERY
THYROID
URINE
VARIATIONS
VASOPRESSIN