THE NEUROHYPOPHYSIS IN POSTIRRADIATION POLYURIA

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Physiologia Bohemoslovaca (Czechoslovakia)

OSTI ID:4093038

Holecek, V; Petrasek, J; Schreiber, V; Dienstbier, Z; Kmentova, V

Large doses of whole-body irradiation with x rays are followed by a temporary increase in the urine flow; maximum values are reached during the first 24 hours and may attain as much as five fold the initial value. Urine flow, K, Na, and Cl excretion and the concentration of antidiuretic hormone in the neurohypophysis were studied in male Wistar rats exposed to 600-r, whole-body doses of x rays. Irradiation resulted in polyuria, with an almost 2-fold rise in urine volume, accompanied by increased urinary excretion of Na, K, and Cl. The only pronounced change observed, the increase in the antidiuretic hormone concentration in the hypothalamus on the fourth day after irradiation, was evidently a manifestation of starvation rather than a consequence of irradiation. It is concluded that osmotic effects predominate in the causation of polyuria following irradiation. For clinical applications it is recommended that postirradiation polyuria in man should be treated in accordance with the results of tests of osmotic relations in the blood and that there are no grounds for antidiuretic hormone therapy to correct renal impairment. (BBB)

• Research Organization: Charles Univ., Prague
• NSA Number: NSA-18-009875
• OSTI ID: 4093038
• Journal Information: Physiologia Bohemoslovaca (Czechoslovakia), Journal Name: Physiologia Bohemoslovaca (Czechoslovakia) Vol. Vol: 11; ISSN PHBOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIDIURETIC HORMONE
BIOLOGY AND MEDICINE
BLOOD
BODY
CHLORINE
DIFFUSION
DISEASES
GLANDS
HORMONES
KIDNEYS
MAN
MEDICINE
PITUITARY GLAND
POTASSIUM
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SEX
SODIUM
URINE
VARIATIONS
X RADIATION