INCREASED URINARY PSEUDOURIDINE EXCRETION IN RATS FOLLOWING IRRADIATION
Research was conducted to study the effects of radiation exposure on urinary pseudouridine excretion. White female Wistar rats weighing 150-180 g received whole-body irradiation at the rate of 18.9 e/minute. The urines of the animals weee collected in 24 hour periods. Pseudouridine was isolated on Dowex 2 x 8' in foemate cycle and purified by means of paper chromatography. Pure pseudouridine in eluates was determined spectrophotometrically. Maximal urinary pseudouridine excretion in the irradiated animals was noted on the day following exposure, dropping on subsequent days by 25 percent of the values seen prior to irradiation. Increase in urinaey pseudoueidine was practically a linear function of radiation dose. (H.M.G.)
- Research Organization:
- Cancer Research Inst., Bratislava
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-011762
- OSTI ID:
- 4121420
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 201
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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