STIMULATION OF CHOLESTEROL BIOSYNTHESIS FROM ACETATE IN RAT LIVER AND ADRENALS BY WHOLE BODY X-IRRADIATION
Whole-body x irradiation resulted in an increased cholesterol biosymthesis in rat liver and adrenal glands, as measured by the rate of incorporation of either s significant 24 hours postirradiation but was inuch larger at 48 hours, and was proportional to dosage over the range 300 to 2400 r. In livier the increase in rate was about 100%/100 r. Intestine showed no effect and carcass only a slight increase. Mice showed a small increase in hepatic cholesterol biosymthesis but rabbits and guinea pigs no significant change. Rats injected with both acetate-1-C/sub 14/ and H/sup 3/OH gave reason- ably constant ratios of C/sup 14/ and H/sup 3/ in liver and carcass cholesterol in control and irradiated animalss supporting the hypothesis that the use of acetate-1-C/sup 14/ in whole animals under standard conditions is a reliable measure of cholesterol biosynthetic rate. The proximate cause of the increased rate of cholesterol synthesis is postulated to be the decreased concentration; in liver a decrease of 0.12 mg/gm was correlated with a doubling of the synthetic rate. (auth)
- Research Organization:
- Los Alamos Scientific Lab., N. Mex.
- NSA Number:
- NSA-13-014154
- OSTI ID:
- 4247602
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 196; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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