EFFECTS OF X IRRADIATION ON CHOLESTEROL, FATTY ACID AND PROTEIN SYNTHESIS

Technical Report · Tue Jan 01 04:00:00 EST 1957

OSTI ID:4315235

Gould, R G; Bell, V L; Lilly, E H; Keegan, P; Van Ripper, J; Jonnard, M L

Whole-body x irradiation of rats has been shown to result in an increase in the rate of cholesterol biosynthesis in liver and adrenal glands. This has been demonstrated by determination of the incorporation of slices, and by the incorporation of tritium labeled body water into cholesterol. The effect was evident 24 hours after irradiation but was much larger 48 hours after. The increase in rate in liver in intact rats was about 100% per 100 r over the range 300 to 2400 r. X irradiation decreased the cholesterol concentration by about 20% and increased the liver weight about 4O%, 48 hours after irradiation. The effect on fatty acid and protein synthesis and on cholesterol biosynthesis in certain other tissues was also studied and found to be either unchanged or increased to a much smaller extent than cholesterol biosynthesis in liver and the adrenal glands. (auth)

• Research Organization: Los Alamos Scientific Lab., N. Mex.
• DOE Contract Number: W-7405-ENG-36
• NSA Number: NSA-12-015218
• OSTI ID: 4315235
• Report Number(s): LA-2179
• Country of Publication: United States
• Language: English

Related Subjects

ACETATES-- ADRENAL GLANDS-- BIOCHEMISTRY-- BODY-- CARBON 14-- CHOLESTEROL-- LABELLED COMPOUNDS-- LIPIDS-- LIVER-- METABOLISM-- ORGANIC ACIDS-- PROTEINS-- RADIATION EFFECTS-- RATS-- TISSUES-- TRITIUM-- WATER-- X RADIATION
ADRENAL GLANDS-- BIOCHEMISTRY-- CHOLESTEROL-- LIPIDS-- LIVER-- METABOLISM-- ORGANIC ACIDS-- PROTEINS-- QUANTITY RATIO-- RADIATION DOSES-- RADIATION EFFECTS-- RATS-- TISSUES-- VARIATIONS-- WEIGHT-- X RADIATION
BIOLOGY AND MEDICINE