THE DIFFERENTIAL ACTION OF IRRADIATED AND CHEMICALLY TREATED MARROW ON SURVIVAL AND ON THYMIC REGENERATION IN IRRADIATED MICE

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Radiation Research

DOI:https://doi.org/10.2307/3570730· OSTI ID:4241485

Berman, I; Kaplan, H S

Bone marrow from x-rayed, thio-TEPA-, and urethantreated donors failed to promote thymic regeneration in sublethally irradiated animals, whereas the same number of cells from the same marrow pools were effective in protecting against the effects of lethal doses of irradiation. The implications of these results are discussed. It is concluded that there are at least two factors or mechanisms of action by which bone marrow independently promotes thymic regeneration and sur vival in x-irradiated animals. It is considered highly unlikely that isologous bone marrow promotes thymic regeneration simply by repopulating the irradiated thymus gland. (auth)

• Research Organization: Stanford Univ., San Francisco
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-016714
• OSTI ID: 4241485
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
CARBAMATES
CHEMICALS
CYTOLOGY
DRUGS
EFFICIENCY
ETHYL RADICALS
LETHAL DOSE
MICE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION PROTECTION
RADIOSENSITIVITY
REGENERATION
SURVIVAL TIME
THIO-TEPA
THYMUS
TRANSPLANTS
URETHANE
VARIATIONS
X RADIATION