Thymic regeneration in lethally x-irradiated mice

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Radiat. Res., v. 64, no. 2, pp. 293-305

DOI:https://doi.org/10.2307/3574266· OSTI ID:4105164

Sharp, J G; Thomas, D B

The effects of a lethal dose of 750 rad of whole-body x irradiation on the murine lymphomyeloid complex have been investigated. During the first 4 days after exposure there was a marked decrease in the weight of the thymus, spleen, and lymph nodes and in the cellularity of the femoral bone marrow. Subsequently, a phase of thymic regeneration, maximal on the tenth day, was observed in the absence of detectable regeneration elsewhere in the lymphomyeloid complex. The thymus, from the third to the fifth days postirradiation, although very hypocellular, was a site of extensive tritiated thymidine incorporation indicating the presence of a precursor cell population undertaking DNA synthesis. No comparable changes in the tritiated thymidine incorporation of the spleen, lymph nodes or bone marrow were observed. Thymic regeneration in the absence of detectable regeneration elsewhere in the lymphomyeloid complex occurred over a range of doses within the lethal range in several strains of mice. (auth)

• Research Organization: Univ. of Birmingham, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-017447
• OSTI ID: 4105164
• Journal Information: Radiat. Res., v. 64, no. 2, pp. 293-305, Journal Name: Radiat. Res., v. 64, no. 2, pp. 293-305; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*BONE MARROW-- BIOLOGICAL RADIATION EFFECTS
*LIVER-- BIOLOGICAL RADIATION EFFECTS
*SPLEEN-- BIOLOGICAL RADIATION EFFECTS
*THYMUS-- BIOLOGICAL REGENERATION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
LETHAL IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
WHOLE-BODY IRRADIATION
X RADIATION