THE EFFECT OF PYRIMIDINE DEOXYRIBONUCLEOTIDES ON THE HAEMATOPOIETIC TISSUE OF IRRADIATED MICE
Experiments were carried out in mice irradiated with 500 r, investigating stimulation of regeneration of hematopoiesis by centain nucleotides and -sides injected after irradiation. The results were evaluated by survival, the blood picture, the mitotic index in the bone marrow, and DNA synthesis in the spleen. Pyrimidine deoxyribonucleotides had a positive effect, while under the given conditions the other substances tested (pyrimidine deoxyribonucleosides, purine deoxyribonucleotides and some ribonucleotides) did not promote regeneration. The authors assume that pyrimidine deoxyribonucleotides are one of the factors determining physiological proliferation of hematopoietic cells or spontaneous regeneration of hematopoiesis after irradiation. (auth)
- Research Organization:
- Czechoslovak Academy of Sciences, Brno
- NSA Number:
- NSA-13-017694
- OSTI ID:
- 4235142
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 5; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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