THE EFFECT OF PYRIMIDINE DEOXYRIBONUCLEOTIDES ON THE HAEMATOPOIETIC TISSUE OF IRRADIATED MICE

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Folia Biologica (Prague) (Czechoslovakia)

OSTI ID:4235142

Soska, J; Karpfel, Z; Drasil, V

Experiments were carried out in mice irradiated with 500 r, investigating stimulation of regeneration of hematopoiesis by centain nucleotides and -sides injected after irradiation. The results were evaluated by survival, the blood picture, the mitotic index in the bone marrow, and DNA synthesis in the spleen. Pyrimidine deoxyribonucleotides had a positive effect, while under the given conditions the other substances tested (pyrimidine deoxyribonucleosides, purine deoxyribonucleotides and some ribonucleotides) did not promote regeneration. The authors assume that pyrimidine deoxyribonucleotides are one of the factors determining physiological proliferation of hematopoietic cells or spontaneous regeneration of hematopoiesis after irradiation. (auth)

• Research Organization: Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-13-017694
• OSTI ID: 4235142
• Journal Information: Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 5; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD FORMATION
BONE MARROW
EFFICIENCY
MICE
MITOSIS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC NITROGEN COMPOUNDS
PHYSIOLOGY
PROTEINS
PURINES
PYRIMIDINES
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
REGENERATION
SPLEEN
SURVIVAL TIME
VARIATIONS