STUDY OF DESTRUCTIVE AND REGENERATIVE PROCESSES IN THE HAEMATOPOIETIC SYSTEM FOLLOWING IRRADIATION
Primary changes in the hematopoietic organs after whole-body and local exposure to x rays showed no fundamental differences. The cellular elements were destroyed only after the direct action of radiation on these cells. No destruction of the cells occurred in shielded parts of the bone marrow and spleen. The cells of spleen irradiated in vivo and temporarily isolated (by ligature of the vascular stem) did not disintegrate. Destruction occurred only after renewing the function of the organ. On removing the irradiated spleen, no early destruction (within 4 to 6 hours) of the cells was observed. Bone marrow cells irradiated in vitro did not regenerate hematopoiesis in irradiated animals. The radiosensitivity of the cells of hematopoietic organs was basically the same in vivo and in vitro. The cells disintegrated, however, only on a functioning injured substrate. If different parts of the hematopoietic system were shielded, the rate of regeneration of the irradiated parts was higher, owing to the presence of an intact focus of hematopoiesis in the organism. Regeneration of the different forms of cells was much more rapid after the injection of isologous cells than after the implantation of heterologous tissue by the same technique. Intravenous administration was also more satisfactory than intraperitoneal administration for the regeneration of hematopoietic tissue in irradiated aninnals. The processes of differentiation of the cells did not basically differ from normal in the regeneration of bone marrow cellular elements in irradiated animals. (auth)
- Research Organization:
- Inst. of Animal Morphology, Academy of Sciences, Moscow
- NSA Number:
- NSA-15-023308
- OSTI ID:
- 4058305
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 7; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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