STUDY OF REGENERATION PROCESSES IN THE BONE MARROW OF IRRADIATED MICE FOLLOWING THE ADMINISTRATION OF PYRIMIDINE DEOXYRIBONUCLEOTIDES
Desoxycytidylic or thymidylic acid was administered to mice irradiatad with a dose of 500 to 600 r. After administration of these desoxymcleotides an increase in mitotic activity was observed in the bone marrow, togather with stimulation of regeneration. The least mature cell forms in the bone marrow reacied most promptly to the administration of thymidylic acid by proliferation. After the adminiatration of the deaoxyribonucleotide, rather More chromosomal aberrations were found than in the irradiated control. Irradiation significantly lowered the prophase to metaphase raiio. This ratio returned io normal 4 to 10 days after irradiation. recovery being significantly more rapid after the administration of the desoxynucleotide than in the irradiated control. (auth)
- Research Organization:
- Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno; Inst. of Animal Morphology, Academy of Sciences, Moscow
- NSA Number:
- NSA-14-021313
- OSTI ID:
- 4167097
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 6; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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