STUDY OF REGENERATION PROCESSES IN THE BONE MARROW OF IRRADIATED MICE FOLLOWING THE ADMINISTRATION OF PYRIMIDINE DEOXYRIBONUCLEOTIDES

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Folia Biologica (Prague) (Czechoslovakia)

OSTI ID:4167097

Karpfel, Z; Soska, J; Barakina, N F

Desoxycytidylic or thymidylic acid was administered to mice irradiatad with a dose of 500 to 600 r. After administration of these desoxymcleotides an increase in mitotic activity was observed in the bone marrow, togather with stimulation of regeneration. The least mature cell forms in the bone marrow reacied most promptly to the administration of thymidylic acid by proliferation. After the adminiatration of the deaoxyribonucleotide, rather More chromosomal aberrations were found than in the irradiated control. Irradiation significantly lowered the prophase to metaphase raiio. This ratio returned io normal 4 to 10 days after irradiation. recovery being significantly more rapid after the administration of the desoxynucleotide than in the irradiated control. (auth)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno; Inst. of Animal Morphology, Academy of Sciences, Moscow
• NSA Number: NSA-14-021313
• OSTI ID: 4167097
• Journal Information: Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 6; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
CHROMOSOMES
EFFICIENCY
IRRADIATION
MICE
MITOSIS
MUTATIONS
NUCLEIC ACIDS
ORGANIC NITROGEN COMPOUNDS
RADIATION DOSES
RECOVERY
REGENERATION
THYMIDYLIC ACID