THE EFFECT OF CERTAIN NUCLEOTIDES AND NUCLEOSIDES ON THE REGENERATION OF HEMOPOIETIC TISSUE AFTER IRRADIATION

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Biofizika (U.S.S.R.) For English translation see Biophysics (Engl. Transl.)

OSTI ID:4222337

Kar-fel', Z; Soshka, Yu; Drashil, V

Since it has been demonstrated by many researchers that the synthesis of desoxyribonucleic acid is signiflcantly decreased after irradiation, an attempt to modify desoxyribonucleic acid (DNA) synthesis and through this modification cause the regeneration of hematopoietic tissue by the use of certain nucleotides and nucleosides that are part of the DNA molecule, is reported. The effect of desoxyribonucleotides and desoxyribonucleosides was evaluated according to the blood picture, and the effect of desoxycytidylic acid and cytidylic acid was studied with regard to the synthesis of DNA in vitro bone marrow suspensions, and in vivo tests on mice. Results verify that of the substances used, desoxyribonucleotides which contain the pyrimidine base exert the most favorable postirradiation effect both on the blood picture and on animal survival. In this research, desoxycytidylic acid, and its mixture with thymidylic acid, when used in small dose, exerted the sides had a favorable effect. Ribonucleotides were ineffective. (auth)

• Research Organization: Czechoslovak Academy of Sciences, Prague
• NSA Number: NSA-13-020810
• OSTI ID: 4222337
• Journal Information: Biofizika (U.S.S.R.) For English translation see Biophysics (Engl. Transl.), Journal Name: Biofizika (U.S.S.R.) For English translation see Biophysics (Engl. Transl.) Vol. Vol: 4; ISSN BIOFA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD
BLOOD FORMATION
BONE MARROW
CHEMICAL REACTIONS
CYTIDYLIC ACID
DNA
EFFICIENCY
IRRADIATION
METABOLISM
MICE
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION INJURIES
REACTION KINETICS
REGENERATION
RIBONUCLEIC ACID
SURVIVAL TIME
SUSPENSIONS
TESTING
THYMIDYLIC ACID
TISSUES
VARIATIONS