Comparative metabolism of calcium and strontium in the rat
Journal Article
·
· Archives of Biochemistry and Biophysics
The comparative metabolism of calcium and strontium was studied in the rat. Animals were injected intraperitoneally, under varying conditions, with solutions containing Sr/sup 89/ and Ca/sup 45/. The appearance of these isotopes. with the passage of time, was observed in the tibia, dentin, plasma, and urine by periodic sacrifice from experimental groups. After 10 days of daily injection, the bone and dentin of the rats contained 30% more Ca/sup 45/ than Sr/ sup 89/. Time sequence retention studies also showed that the Sr/sup 89:Ca/sup 45/ ratio of the plasma remained near unity during the experiments, while the urine ratio continuously fell with the passage of time. Examination of the feces 24 hr after injection revealed a reduced ratio as in the case of urine. Ultrafiltratlon experiments showed that bound Ca/sup 45/ and Sr/sup 89/ in the plasma were essentially the same 1 hr and 12 hr after injection. Thus, the continuous drop in ratio in urine could not be explained by preferential binding of Ca/sup 45/ in the plasma. Synthetic hydroxyapatite samples tagged with Sr/sup 45/ and Ca/sup 45/ exhibited a preferential loss of Sr/sup 89/ when the samples were shaken with calcium acetate solution. The apatites were prepared by hydrolysis of CaHPO/sub 4/ and by direct precipitation from solution. The differences between these preparations are discussed. The discrimination of the animal against Ca/sup 45/ in the urine and feces is probably regulated on the bone level as well as by the kidney and gut function. (auth)
- Research Organization:
- U.S. Depart. of Health, Education, and Welfare, Bethesda, Md.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-13-018810
- OSTI ID:
- 4215459
- Journal Information:
- Archives of Biochemistry and Biophysics, Journal Name: Archives of Biochemistry and Biophysics Journal Issue: 2 Vol. 83; ISSN 0003-9861
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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