COMPARATIVE FIXATION OF Sr$sup 89$ AND Ca$sup 45$ BY CALCIFIED TISSUES AS RELATED TO FLUORIDE INDUCED CHANGES IN CRYSTALLINITY
X ray diffraction analyses, and Sr/sup 89/ and Ca/sup 45/ uptake studies in tibiac and incisors of control and fluoride treated one-year-old rats were carried out. In the tibia ends and shafts an improvement of bone apatite crystallinity in the direction of the a axis and not the c axis was produced by fluoride ingestion. No changes in incisor apatite crystallinity were observed. Uptake of Ca/sup 45/ and Sr/sup 89/ was decreased in the tibia ends of the 25 and 50 ppm F treated animals. Sr/sup 89//Ca/sup 45/ ratios in the tibia samples were the same as in the serum specimens. There was a discrimination against Sr in relation to Ca in the incisor bases. Radioactivity in the tibia of one-year-old animals was 1/40 to 1/50 of that found in a group of young animals treated similarly in an earlier experiment. In the young rat the tibia ends were found to incorporate more Sr/sup 89/ and Ca/sup 45/ than the incisor, while the opposite was found in the older rats. (auth)
- Research Organization:
- National Inst. of Dental Research, Bethesda, Md.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-028722
- OSTI ID:
- 4792110
- Journal Information:
- Proc. Soc. Exptl. Biol. Med., Vol. Vol: 110; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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