CHANGES OF MUCOPOLYSACCHARIDE CONTENT AND OF HYALURONIDASE INHIBITOR ACTIVITY IN THE BLOOD AND TISSUES DURING ACUTE RADIATION SICKNESS

Journal Article · Tue Dec 01 04:00:00 EST 1959 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4205361

Sheremet, Z I; Manteifel, V M; Rayshenbakh, M O ^[1]

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1. Raushenbach

The changes in the amount of polysaccharides and the hyaluronidase activity in the tissues of the small intestine, storoach, lungs, and blood serum of guinea pigs, white rats, and dogs at various periods of acute radiation sickness were studied. Mucopolysaccharides were determined by the content of glucosamine and tyrosine by Elson and Morgan's method and by the amount of mucoid isolated by Glass-Loyd' s method. Biological membrane permeability, viscosimetric, and mucine clot formation methods were used for the determination of the fermentative activity of hyaluroridase. A decrease of mucopolysaccharide content was noted in the tissues of the small intestine, stomach, lungs, and liver during the development of radiation sickness in guinea pigs. In rats a short-term reduction of mucopolysaccharide content was observed in the small intestine; in the rest of the tissues its rise was revealed. Serum mucoproteid content increased in all the animals after the irradiation. No rise of the hyaluroridase activity was noted under the effect of irradiation in the tissues investigated. Properties of the blood serum and of some tissue extracts inhibiting hyaluronidase activity were increased. Treatment of acute radiation sickness with hyaluronic acid and vitreous body did not prove successful. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-14-006183
• OSTI ID: 4205361
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 12; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINES
AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD SERUM
CARBOHYDRATES
CHEMICAL REACTIONS
DOGS
ENZYMES
EYES
FERMENTATION
GLUCURONIC ACID
GUINEA PIGS
HYALURONIC ACID
HYALURONIDASE
INTESTINE
LIVER
LUNGS
MEMBRANES
ORGANIC ACIDS
POLYMERS
POLYSACCHARIDES
PROTEINS
RADIATION SICKNESS
RATS
STOMACH
TISSUES
TYROSINE
VISCOSITY