THE PROPERDIN SYSTEM IN ACUTE RADIATION SICKNESS (in Russian)
In acute radiation sickness in dogs, mice, guinea pigs, and rats, caused by total x irradiation in the dose of LD 75 to 100, a drop of the properdin level was observed in the second half of the disease, usually several days before the death of animals. In the surviving dogs, as a rule, no drop of the properdin level in the blood was noted. In the surviving dogs, as a rule, no drop of the properdin level in the blood was noted. In rabbits affected with acute lethal radiation sickness there was seen no decrease of the properdin system activity. The properdin titer in monkeys usually decreased soon after the irradiation: the activity of the properdin system was not restored even after full clinical recovery. On the basis of experimental data it is surmised that the drop of the properdin level in the blood in acute radiation sickness can be explained by its combination with mucopolysaccharides, which were freed from tissues in the process of development of the disease. (auth) l5866 The sharpest increase of vascular permeability following irradiation of rabbits (1,000 r) takes place in the first hours after irradiation. At this time there is a sharp increase of quantity of the intravenously introduced fluorescin in the anterior chamber of the eye, as compared to normal conditions. The resistance of capiliaries of the rabbits small intestine in relation to the rate of external pressure, causing hemorrhages in the intestinal wall drops more considerably at late stages of radiation sickness. The period of largest changes of vascular resistance coincides with the time of appearance of hemorrhages in internal organs of the animal. (auth)
- Research Organization:
- Order of Lenin Inst. of Hematology and Blood Transfusion
- NSA Number:
- NSA-13-015865
- OSTI ID:
- 4247838
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Vol. Vol: 4, No. 4; Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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