THE SIGNIFICANCE OF THE ALTERED SEROTONIN METABOLISM FOR THE GENESIS OF RADIATION CONDITIONED HAEMORRHAGE (in German)
Monkeys, dogs, guinea-pigs, rats, and mice showed a direct dependence between the pronounced symptoms of the hemorrhagic syndrome and the degree of the disturbance of serotonin metabolism in the organism with the acute radiation sickness. With the acute form of the disease there was seen a strong decline of the serotonin level in the blood temporarily combined with the clinical appearance of the hemorrhagic syndrome; with the mild course of radiation sickness of these changes were less pronounced. It was shown that in the acute stage of the disease a decline of the activity of the extracerebral 5-OTD (5- oxytrypto-decarboxylase) as well as a decline of the serotonin content occurred in the intestine, whereas the serotonin level in the brain and the activity of the cerebral 5-OTD showed no significant changes under the same conditions. Data are included on the changes of the MAO-activity (Monoaminooxydase) in the intestine, brain, and liver, during acute radiation sickness. (auth)
- Research Organization:
- Central Inst. for Hematology and Blood Transfusion, USSR
- NSA Number:
- NSA-17-033741
- OSTI ID:
- 4659645
- Journal Information:
- Radiobiol. Radiotherap., Vol. Vol: 4; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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