STUDIES ON PASSIVE REACTION MECHANISMS OF RADIATION-PRODUCED RESISTANCE FACTORS OF THE LIVER AND SPLEEN WITH ALLYL-ALCOHOL DAMAGE

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Strahlentherapie (West Germany)

OSTI ID:4191463

Eger, W; Hildebrandt, W; Poppe, H

Intraperitoneally given homogenate of liver from normal rats provides in other rats a protective action upon the liver, which has already been damaged by allyl alcohol. The homogenate of radiated animals shows a more marked action. The protective factor is found exclusively in the cytoplasm of the liver cell. whereas it is not found in the nuclei of cells and the mytochondria. In this fraction the protective factor ot radiated animals is found to increase. The protective factor is thermolabil, it can be extracted by ether and proved in the residue of ether. The residual substance of the volatilized ether loses its action. The homogerate of the spleen of normal rats possesses no necrotropic characteristic toward liver, which has been damaged by ally alcohol. On the contrary the spleens of radiated animals have hhown a necrotropic defensive action. The removal of the spleen reduces the ability of animals, after radiation, to increase their resistance to allyl alcohol. The blood-serum and blood clots contain no liver protecting factor. (auth)

• Research Organization: Universitat, Gottingen, Ger.
• NSA Number: NSA-14-008380
• OSTI ID: 4191463
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 111; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ALCOHOLS
ALLYL RADICALS
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD
BLOOD SERUM
CHEMICAL REACTIONS
COAGULATION
CYTOLOGY
ETHERS
HOMOGENEOUS REACTORS
IRRADIATION
LIVER
RADIATION PROTECTION
RATS
SEPARATION PROCESSES
SOLUBILITY
SPLEEN
SURGERY
TEMPERATURE