ANIMAL EXPERIMENTS ON THE COMBINED TREATMENT OF RADIATION INJURIES IN BLOOD- FORMING BONE MARROW WITH SPLEEN HOMOGENATE AND ATP

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Strahlentherapie (West Germany)

OSTI ID:4191501

Thom, H

Inbreed rats were irradidted with 800 rep 15 Mev electrons. Immediately following the irradiation a single i.v. injection of 0.5 ml spleen homogerate, obtained from 70 x 10/sup 6/ homologous spleen cells. was given. Also immediately following the irradiation and at the 3 following days 10 mg (= 0.5 ml) ATP were injected i.m. As in previous experiments with the only use of spleen cell suspension or spleen homogenate the combined treatment with spleen homogenate and ATP did not show an effect on the initial phase of damage in the blood forming bone marrow. However, the course of the qualitative and quantitative regeneration with a histologic restitution after 14 days as compared to 21 days of untreated control animals was more rapid. The better course of regeneration concerns principally the erythropoesis, but significantly also the myelopoesis. In contrast to the only treatment with spleen cell suspension or spleen homogenate the combined use of spleen homogenate and ATP has also an effect on the peripheral blood count: the neutrophile granulocytes and the hemoglobin have reached normal values in 3 weeks, the errhrocytes stay at the lower limit of normal. There is no effect on the peripheral lymphocyte count. (auth)

• Research Organization: Universitat, Heidelberg, Ger.
• NSA Number: NSA-14-008377
• OSTI ID: 4191501
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 111; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ATP
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
CONTROL
ELECTRON BEAMS
ENZYMES
ERYTHROCYTES
HEMOGLOBIN
IRRADIATION
LEUCOCYTES
NEUTROPHILS
RADIATION DOSES
RADIATION INJURIES
RATS
RECOVERY
REGENERATION
SPLEEN
SUSPENSIONS
TISSUES
USES