EFFECTS OF SPLENECTOMY AND OF TREATMENT WITH SPLEEN HOMOGENATES IN ANIMALS SUBJECTED TO WHOLE-BODY IRRADIATION

Journal Article · Fri Sep 15 04:00:00 EDT 1961 · Boll. Soc. Ital. Biol. Sper.

OSTI ID:4748280

De Franciscis, P; Cifaldi, S; Muto, V

Male mice were given a single whole-body dose of 1000-r, 160-kv x rays 10 days after splenectomy or immediately before injection of homogenized spleen. The homogenate was injected intraperitoneally in an amount equivalent to a single spleen; some controls were injected with spleen that had been boiled for 5 min to denature proteins. The 10-day mortality rate was 60% in untreated controls, 23% in splenectomized animals, and 25 and 90% in animals given fresh and heat-treated spleen homogenate, respectively. The 15day mortality rates in the 4 groups were 75, 50, 40, and 90%, respectively. The results show that prior splenectomy has a similar protective effect to injection of fresh spleen, whereas injection of heated spleen markedly increases radiosensitivity. The protective factor in spleen, therefore, is a thermolabile substance, possibly protein in nature. (H.H.D.)

• Research Organization: Universita, Naples
• NSA Number: NSA-17-015811
• OSTI ID: 4748280
• Journal Information: Boll. Soc. Ital. Biol. Sper., Journal Name: Boll. Soc. Ital. Biol. Sper. Vol. Vol: 37
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
EFFICIENCY
ENERGY
HIGH TEMPERATURE
HOMOGENEOUS REACTORS
MEDICINE
MICE
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RADIOSENSITIVITY
SPLEEN
SURGERY
SURVIVAL TIME
TRANSPLANTS
VARIATIONS
X RADIATION