Acute and late effects of 16- and 50-MeV/sub d $Yields$ Be/ neutrons on the oral mucosa of Rhesus monkeys

Conference · Wed Oct 01 04:00:00 EDT 1975 · Radiology, v. 117, no. 1, pp. 185-190

OSTI ID:4191371

Jardine, J H; Hussey, D H; Boyd, D D; Raulston, G L; Davidson, T J

Twenty-five rhesus monkeys were randomly assigned to one of five mouth irradiation treatment schedules: control group, no irradiation; $sup 60$Co $gamma$ five times weekly; $sup 60$Co twice weekly; 16-MeV/sub d$Yields$Be/ neutrons twice weekly. Although the acute reactions of the oral mucosa were similar in the four irradiated groups, the late sequelae were more severe in the animals irradiated twice weekly with $sup 60$Co $gamma$ or neutrons. All of the animals irradiated with $sup 60$Co $gamma$ twice weekly or with 16 MeV/sub d$Yields$Be/ neutrons exhibited oromucosal necrosis, whereas none of those irradiated five times weekly with $sup 60$Co $gamma$ did. The difference in the effect of photon fractionation on early and late radiation sequelae may be related to different patterns of redistribution of surviving cells through the division cycle in tissues responsible for early and late damage. (auth)

• Research Organization: Univ. of Texas, Houston
• NSA Number: NSA-33-000956
• OSTI ID: 4191371
• Conference Information: Journal Name: Radiology, v. 117, no. 1, pp. 185-190
• Country of Publication: United States
• Language: English

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*FAST NEUTRONS-- RBE
*MUCOUS MEMBRANES-- BIOLOGICAL RADIATION EFFECTS
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