Effects of 50 MeV/sub d. -->. Be/ neutron irradiation on Rhesus monkey cervical spinal cord

Journal Article · Sat Mar 01 04:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90134-0· OSTI ID:5072146

Jardine, J H; Hussey, D H; Raulston, G L; Chester, D V.M.; Gleiser, C A; Gray, K N; Huchton, J I; Almond, P R

The cervical spinal cords of ten Rhesus monkeys were irradiated with 50 MeV/sub d ..-->.. Be/ neutrons according to one of two dosage schedules: (1) 1300 rad/ sub n..gamma../ in nine fractions over 29 days, and (2) 1550 rad/sub n..gamma../ in nine fractions over 29 days. These doses are equivalent to 4000 rad/sub eq/ and 4800 rad/sub eq/, respectively, with /sup 60/Co using an RBE of 3.1 for late effects (conventional 200 rad per day fractionation). Whereas none of five monkeys that received a spinal cord dose of 1300 rad/sub n..gamma../ developed signs of neurologic dysfunction, all five animals that were irradiated to a dose of 1550 rad/sub n..gamma../ developed significant radiation myelitis. The histopathologic changes correlated well with the clinical observations. All of the animals that received 1550 rad/sub n..gamma../ exhibited severe malacia and moderate to severe demyelination of the white matter of the cervical spinal cord. The histopathologic changes in the monkeys irradiated with 1300 rad/sub n..gamma../ were minimal by comparison.

• Research Organization: Univ. of Texas System Cancer Center, Houston
• OSTI ID: 5072146
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MACACUS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MONKEYS
NERVOUS SYSTEM
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RBE
SPINAL CORD
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES