50-MeV/sub d. -->. Be/ neutrons: a comparison of normal tissue tolerance in animals with clinical observations in patients

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90549-1· OSTI ID:5145622

Hussey, D H ^[1]; Jardine, J H; Raulston, G L; Stephens, L C; Gray, K N; Maor, M H; Withers, H R

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1. Anderson Hospital and Tumor Inst. at Houston, TX

The acute and late effects of 50 MeV neutrons were investigated by irradiating a variety of organ systems in large animals using dosage schedules similar to those that have been employed clinically. The RBE's for acute effects in pig skin and rhesus monkey oral mucosa were significantly less than the RBE's for late effects. This observation has also been noticed clinically. The RBE's for late effects in pig skin, rhesus monkey oral mucosa, and rhesus monkey kidney were consistent with values of 3.1 to 3.4 relative to approx.200 rad /sup 60/Co fractions and approx.2.2 to 2.6 relative to approx.400 rad /sup 60/Co fractions. The RBE for radiation myelitis was significantly greater (4.2 to 4.6 relative to approx.270 rad /sup 60/Co fractions). The tolerance doses for 50 MeV/sub d..-->..Be/ neutrons in large animals were approx.2200 rad/sub n..gamma..//6-1/2 weeks for skin contraction, approx.2100 rad/sub n..gamma..//6-1/2 weeks for oromucosal necrosis, approx.1300 rad/sub n..gamma..//4-1/2 weeks for radiation myelitis, and approx.960 rad/sub n..gamma..//4 weeks for radiation nephritis. These values correlate well with clinical observations at TAMVEC, since the majority of soft tissue complications in patients occurred following tissue doses in excess of 2100 rad/sub n..gamma../.

• OSTI ID: 5145622
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:12; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DOMESTIC ANIMALS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MEDICINE
MEMBRANES
MINUTES LIVING RADIOISOTOPES
MONKEYS
MUCOUS MEMBRANES
MYELITIS
NECROSIS
NERVOUS SYSTEM DISEASES
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RBE
SIDE EFFECTS
SKIN
SWINE
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES