Late cataractogenesis in rhesus monkeys irradiated with protons and radiogenic cataract in other species

Journal Article · Wed May 01 04:00:00 EDT 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577813· OSTI ID:5734497

Lett, J T; Lee, A C; Cox, A B ^[1]

---

1. Colorado State Univ., Fort Collins (USA)

Rhesus monkeys (Macaca mulatta) which were irradiated at ca. 2 years of age with acute doses (less than or equal to 5 Gy) of protons (32-2300 MeV) are exhibiting the late progressive phase of radiation cataractogenesis 20-24 years after exposure, the period during which we have been monitoring the sequelae of irradiation of the lens. The median life span of the primate is approximately 24 years. Analogous late ocular changes also occur in a similar period of the lifetimes of New Zealand White (NZW) rabbits (Oryctolagus cuniculus) exposed at 8-10 weeks of age to 460-MeV {sup 56}Fe ions. In this experiment, which has been in progress for ca. 6 years, we are following the development of radiation-induced lenticular opacification (cataractogenic profiles) throughout the life span. The median life span of the lagomorph is 5-7 years. Cataractogenic profiles for NZW rabbits irradiated with {sup 20}Ne and {sup 40}Ar ions and {sup 60}Co gamma photons were obtained previously. Reference is also made to measurements of the cataractogenic profiles of a short-lived rodent, the Fischer 344 rat (Rattus norvegicus) during the first year after exposure at 8-10 weeks of age to spread-Bragg-peak protons of 55 MeV nominal energy. The median life span of the rodent is reported to be 2-3 years.

• OSTI ID: 5734497
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 126:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CATARACTS
CRYSTALLINE LENS
DISEASES
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
EYES
FACE
FERMIONS
HADRONS
HEAD
INTERMEDIATE MASS NUCLEI
IRON 56
IRON ISOTOPES
ISOTOPES
MAMMALS
MONKEYS
NUCLEI
NUCLEONS
ORGANS
PRIMATES
PROTONS
RABBITS
RADIATION EFFECTS
RADIOINDUCTION
RATS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
SPACE FLIGHT
STABLE ISOTOPES
VERTEBRATES