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Some perspectives on cataractogenesis from heavy charged particles

Journal Article · · Radiat. Res., Suppl.; (United States)
DOI:https://doi.org/10.2307/3583528· OSTI ID:5326061
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Two sets of observations on cataractogenesis in the New Zealand white (NZW) rabbit (Oryctolagus cuniculus) following localized exposure of optic and proximate tissues to heavy ions are reported. The experiments involved measurements of lenticular opacification in young (ca. 9 weeks old) rabbits caused by graded doses (0.5-5.0 Gy) of 460 MeV/u (incident energy) 56Fe ions and the effects of animal age (9 +/- 0.3 week, 1 +/- 0.5 year, and 4.5 +/- 1.3 year) on lenticular opacifications caused by 9 Gy of 400 MeV/u (incident energy) 20Ne ions. In substantiation of earlier results from NZW rabbits exposed to other low- and high-LET radiations, there was a dose-dependent onset of cataractogenesis following 56Fe-ion irradiation, with the highest doses causing the earliest appearance of cataracts. The level of stationary cataracts was also dependent on dose, and preliminary estimates of RBE yield values comparable to those found at similar doses (0.5-5.0 Gy) by others with populations of cultured cells. With increasing age at the time of exposure to 20Ne ions, the onset of lenticular opacification was delayed progressively and the level of stationary cataracts was reduced, but the onset and progression of late cataractogenesis was most rapid in the oldest group of animals. A discussion of the use of cataract measurements in risk assessment is included in this article.
Research Organization:
Colorado State Univ., Fort Collins
OSTI ID:
5326061
Journal Information:
Radiat. Res., Suppl.; (United States), Journal Name: Radiat. Res., Suppl.; (United States); ISSN RARSA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BODY AREAS
CATARACTS
DISEASES
EYES
FACE
HEAD
ION BEAMS
IRON 56 BEAMS
MAMMALS
NEON 20 BEAMS
ORGANS
RABBITS
RADIATION EFFECTS
RADIOBIOLOGY
RADIOINDUCTION
RBE
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES