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Cataractogenesis from high-LET radiation and the Casarett model

Conference · · Adv. Space Res.; (United States)
OSTI ID:6131047
;
The long-term effects on specific animal tissues of exposure to heavy ion irradiation are studied in experiments on cataractogenesis in mice and rabbits. Five groups of rabbits at ages from 8 weeks to 5.3 years were irradiated to a dose of 9.0 Gy of Bragg plateau Ne-20 ions, while mice were exposed to single and total fractionated doses of 4.17 Gy gamma rays or 0.40 to 1.20 Gy of C-12, Ne-20 or Ar-40 particles. Measurements of lens opacities over time show that in the year since irradiation, cataractogenesis is delayed and less severe in rabbits irradiated at age 6 months compared to younger animals, although it is possible that the late effects in adults will surpass those found in the young. The fractionation of the total dose of gamma rays in mice is observed to lead to a marked reduction in the extent of lens opacity after one year, while fractionated heavy ion doses caused a greater degree of posterior lens opacification. Evaluations of the effects of the LET of different ions on cataractogenesis are consistent with RBEs of about 5, 3 and 1-2 for Ar-40, Ne-20 and C-12 ions, respectively. Results thus support the Casarett model of radiation damaging stem cell populations that are not necessarily part of the vasculature. 41 references.
Research Organization:
Colorado State Univ., Fort Collins
DOE Contract Number:
W-7405-ENG-48
OSTI ID:
6131047
Report Number(s):
CONF-820582-
Conference Information:
Journal Name: Adv. Space Res.; (United States) Journal Volume: 3
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASTRONAUTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CATARACTS
CHARGED PARTICLES
COSMIC NUCLEI
COSMIC RADIATION
DISEASES
HAZARDS
HEALTH HAZARDS
HEAVY IONS
IONIZING RADIATIONS
IONS
MAMMALS
MICE
NUCLEI
PERSONNEL
RABBITS
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOBIOLOGY
RODENTS
SENSE ORGANS DISEASES
VERTEBRATES